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Tricyclic Antidepressants Are Still A Good Choice For Treating Depression Tricyclic antidepressants is one of the more popular drugs used to fight depression in people today. Known as the “first generation” antidepressants because Tricyclic antidepressants were the first medications to come into use in the 1950's to treat depression. They are still one of the better drugs to treat not only depression but have been found to treat chronic pain also. None of the Tricyclic antidepressants have been approved by the government to be used for chronic pain...